Shopping Cart
In Vivo Ready™ Anti-Mouse CD8a (53-6.7)

In Vivo Ready™ Anti-Mouse CD8a (53-6.7)

SKU 40-0081-U100
Regular price

$83.00

task_alt Added to cart.
View Cart or Continue shopping.
Description

The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

The 53-6.7 antibody is widely used as a phenotypic marker for mouse CD8a expression on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.

Name In Vivo Ready™ Anti-Mouse CD8a (53-6.7)
Cat. No. 40-0081
Data Sheets TDS | SDS
Alternative Names CD8 alpha, Ly-2, Ly-35, Ly-B, Lyt-2
Gene ID 12525
Clone 53-6.7
Isotype Rat IgG2a, κ
Reactivity Mouse
Format In Vivo Ready™
Application FC - Validated
FA, IHCF, IHCP, IP - Reported in literature, not validated in house

For Research Use Only. Not intended for use in diagnostic procedures.

Shipping
Price calculated at checkout.