Shopping Cart
In Vivo Ready™ Anti-Mouse CD3e (145-2C11)

In Vivo Ready™ Anti-Mouse CD3e (145-2C11)

SKU 40-0031-U100
Regular price

$66.00

task_alt Added to cart.
View Cart or Continue shopping.
Description

TDS | SDS

The 145-2C11 antibody is specific for mouse CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.

The 145-2C11 antibody is a widely used phenotypic marker for mouse T cells. In addition, binding of 145-2C11 antibody to CD3e can induce cell activation. A recent publication of the crystal structure of a murine CD3e-mitogenic antibody complex provides further insight into the action of commonly used agonist antibodies (Fernandes, R.A. et al. 2012. J. Biol. Chem. 287: 13324-13335).

 

Recent Citations:

Ortega-Molina A, Lebrero-Fernández C, Sanz A, et al. Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs. Cell Rep. 2021 Jul 13;36(2):109372. doi: 10.1016/j.celrep.2021.109372. PMID: 34260908. 

» View on ScienceDirect

Name In Vivo Ready™ Anti-Mouse CD3e (145-2C11)
Cat. No. 40-0031
Alternative Names CD3 epsilon
Gene ID 12501
Clone 145-2C11
Isotype Armenian Hamster IgG
Reactivity Mouse
Format In Vivo Ready™
Application Flow Cytometry, Functional Assays, IF, IHCF, IP, Western Blot
Shipping
Price calculated at checkout.