Shopping Cart
In Vivo Ready™ Anti-Mouse CD115 (c-fms) (AFS98)

In Vivo Ready™ Anti-Mouse CD115 (c-fms) (AFS98)

SKU 40-1152-U100
Regular price

$144.00

task_alt Added to cart.
View Cart or Continue shopping.
Description

TDS | SDS

The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerization of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.

The AFS98 antibody may be used for identification of myeloid lineage cells by flow cytometry, and is commonly used for in vivo or in vitro neutralization of CSF-1 Receptor.

Name In Vivo Ready™ Anti-Mouse CD115 (c-fms) (AFS98)
Cat. No. 40-1152
Alternative Names CSF-1-R, FMS, Colony-Stimulating Factor 1 Receptor, M-CSF Receptor, CSF1R
Gene ID 12978
Clone AFS98
Isotype Rat IgG2a, κ
Reactivity Mouse
Format In Vivo Ready™
Application Flow Cytometry, Functional Assays, Western Blot
Shipping
Price calculated at checkout.