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C57Bl/6 splenocytes were stained with 0.25 ug FITC Anti-Mouse MHC Class II (35-5321) (solid line) or 0.25 ug FITC Rat IgG2b isotype control (dashed line).

FITC Anti-Mouse MHC Class II (I-A/I-E) (M5/114.15.2)

SKU 35-5321-U025
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$29.00

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Description

TDS | SDS

The M5/114.15.2 antibody reacts with mouse MHC Class II alloantigens I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek, as well as being cross-reactive with mouse cells of H-2p and H-2r haplotype. MHC Class II is widely expressed by mouse immune cells bearing these alloantigens, including T and B cells, monocytes, macrophages, and dendritic cells. The antibody does not react with the following alloantigens: I-Af, I-Ak, I-As, or NOD H-2g7

The M5/114.15.2 antibody may be used for analysis of mouse cells expressing MHC Class II alloantigens as described. Please note that the M5/114.15.2 clone may also be referred to as M5/114 in the literature.

 

Recent Citations:

Vachon L, Smaani A, Tessier N, Jean G, Demers A, Milasan A, Ardo N, Jarry S, Villeneuve L, Alikashani A, Finherty V, Ruiz M, Sorci-Thomas MG, Mayer G, Martel C. Downregulation of low-density lipoprotein receptor mRNA in lymphatic endothelial cells impairs lymphatic function through changes in intracellular lipids. Theranostics. 2022 Jan 1;12(3):1440-1458. doi: 10.7150/thno.58780. PMID: 35154499; PMCID: PMC8771568.

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Ortega-Molina A, Lebrero-Fernández C, Sanz A, et al. Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs. Cell Rep. 2021 Jul 13;36(2):109372. doi: 10.1016/j.celrep.2021.109372. PMID: 34260908. 

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Name FITC Anti-Mouse MHC Class II (I-A/I-E) (M5/114.15.2)
Cat. No. 35-5321
Alternative Names MHC II, IA, IE, I-A/E, IA/IE
Gene ID 14961/14969
Clone M5/114.15.2
Isotype Rat IgG2b, κ
Reactivity Mouse
Format FITC
Application Flow Cytometry
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