FITC Anti-Mouse MHC Class II (I-A/I-E) (M5/114.15.2)
The M5/114.15.2 antibody reacts with mouse MHC Class II alloantigens I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek, as well as being cross-reactive with mouse cells of H-2p and H-2r haplotype. MHC Class II is widely expressed by mouse immune cells bearing these alloantigens, including T and B cells, monocytes, macrophages, and dendritic cells. The antibody does not react with the following alloantigens: I-Af, I-Ak, I-As, or NOD H-2g7
The M5/114.15.2 antibody may be used for analysis of mouse cells expressing MHC Class II alloantigens as described. Please note that the M5/114.15.2 clone may also be referred to as M5/114 in the literature.
Vachon L, Smaani A, Tessier N, Jean G, Demers A, Milasan A, Ardo N, Jarry S, Villeneuve L, Alikashani A, Finherty V, Ruiz M, Sorci-Thomas MG, Mayer G, Martel C. Downregulation of low-density lipoprotein receptor mRNA in lymphatic endothelial cells impairs lymphatic function through changes in intracellular lipids. Theranostics. 2022 Jan 1;12(3):1440-1458. doi: 10.7150/thno.58780. PMID: 35154499; PMCID: PMC8771568.
Ortega-Molina A, Lebrero-Fernández C, Sanz A, et al. Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs. Cell Rep. 2021 Jul 13;36(2):109372. doi: 10.1016/j.celrep.2021.109372. PMID: 34260908.
|Name||FITC Anti-Mouse MHC Class II (I-A/I-E) (M5/114.15.2)|
|Alternative Names||MHC II, IA, IE, I-A/E, IA/IE|
|Isotype||Rat IgG2b, κ|