The rat monoclonal antibody clone GL-1 binds to mouse CD86, also known as B7-2. This 80 kDa cell surface protein is a ligand for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 can also bind a second B7 ligand known as CD80 (B7-1). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.

PRODUCT DETAILS

Clone: GL-1 (GL1)

Specificity: CD86 (B7-2)

Reactivity: Mouse

Format: FITC

Isotype: Rat IgG2a, k

Application: FC

Storage: 2-8°C protected from light.Do not freeze

Formulation: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: The suggested use of this reagent is 1-5 μg/ml. It is recommended that users titrate the antibody to obtain the optimal result for their specific application.

For research use only. Not intended for use in diagnostic procedures.