FITC Anti-Mouse CD86 (B7-2) (GL-1)
The GL-1 antibody reacts with mouse CD86, also known as B7-2, an 80 kDa cell surface protein which is a ligand for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 can also bind a second B7 ligand known as CD80 (B7-1). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between ≥ ≥ ≥ the B7 ligands and CD28 provides crucial communication between ≥ ≥ ≥ T cells and B cells or APCs to coordinate the adaptive immune response.
The GL-1 antibody may be used as a marker for CD86 expression on B cells, macrophages, and dendritic cells.
Xu L, Su B, Mo L, Zhao C, Zhao Z, Li H, Hu Z, Li J. Norcantharidin Induces Immunogenic Cell Death of Bladder Cancer Cells through Promoting Autophagy in Acidic Culture. Int J Mol Sci. 2022 Apr 1;23(7):3944. doi: 10.3390/ijms23073944. PMID: 35409302; PMCID: PMC8999362.
|Name||FITC Anti-Mouse CD86 (B7-2) (GL-1)|
|Alternative Names||B7.2, B70, Ly-58|
|Isotype||Rat IgG2a, κ|