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C57Bl/6 splenocytes were unstimulated (left panel) or stimulated for 3 days with LPS (right panel) and stained with 0.25 ug FITC Anti-Mouse CD80 (35-0801) (solid line) or 0.25 ug FITC Armenian Hamster isotype control (dashed line).

FITC Anti-Mouse CD80 (B7-1) (16-10A1)

SKU 35-0801-U025
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The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.

Name FITC Anti-Mouse CD80 (B7-1) (16-10A1)
Cat. No. 35-0801
Alternative Names B7, Ly-53
Gene ID 12519
Clone 16-10A1
Isotype Armenian Hamster IgG
Reactivity Mouse
Format FITC
Application Flow Cytometry
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