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C57Bl/6 splenocytes were stained with 0.5 ug FITC Anti-Mouse CD45 (35-0451) (solid line) or 0.5 ug FITC Rat IgG2b isotype control (dashed line).

FITC Anti-Mouse CD45 (30-F11)

SKU 35-0451-U025
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$19.00

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Description

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The 30-F11 antibody reacts with mouse CD45, which is one of the most abundant hematopoietic markers and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, CD45RO and others.

The 30-F11 antibody is widely used as a leukocyte marker for B cells, T cell subsets and NK cell subsets.

Recent Publications:

Itokazu M, Onodera Y, Mori T, Inoue S, Yamagishi K, Moritake A, Iwawaki N, Shigi K, Takehara T, Higashimoto Y, Akagi M, Teramura T. Adipose-derived exosomes block muscular stem cell proliferation in aged mouse by delivering miRNA Let-7d-3p that targets transcription factor HMGA2. J Biol Chem. 2022 Jun 6:102098. doi: 10.1016/j.jbc.2022.102098. Epub ahead of print. PMID: 35679898.

» View on PubMed

Ishikura N, Sugimoto M, Yorozu K, Kurasawa M, Kondoh O. Anti‑VEGF antibody triggers the effect of anti‑PD‑L1 antibody in PD‑L1low and immune desert‑like mouse tumors. Oncol Rep. 2022 Feb;47(2):36. doi: 10.3892/or.2021.8247. Epub 2021 Dec 27. PMID: 34958105.

» View on PubMed

Baniel CC, Sumiec EG, Hank JA, Bates AM, et al. Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model. J Immunother Cancer. 2020 Oct;8(2):e001262. doi: 10.1136/jitc-2020-001262. PMID: 33115944.

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Diaz-Flores E, Comeaux EQ, Kim KL, et al. Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia. Cancer Res. 2019;79(9):2339-2351. doi:10.1158/0008-5472.CAN-18-0236.

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Benck CJ, Martinov T, Fife BT and Chatterjea D. 2016. J. Vis. Exp. (107), e53638, doi:10.3791/53638. (Flow Cytometry)

Name FITC Anti-Mouse CD45 (30-F11)
Cat. No. 35-0451
Alternative Names Leukocyte Common Antigen, LCA, Ly-5
Gene ID 19264
Clone 30-F11
Isotype Rat IgG2b, κ
Reactivity Mouse
Format FITC
Application Flow Cytometry
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