FITC Anti-Mouse CD45.1 (A20)
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The A20 antibody reacts with mouse CD45.1, also known as Ly5.1, which is a strain-specific allelic form of the CD45 Leukocyte Common Antigen (LCA). Functionally, CD45 is a protein tyrosine phosphatase whose broad cell distribution supports a critical role in many leukocyte functions, including regulation of signal transduction and cell activation associated with the T cell and B cell receptors.
The A20 antibody is typically used as a leukocyte marker in Ly5.1 mouse strains: SJL/J, DA, STS/A and RIII. The antibody has been demonstrated to specific for CD45.1 and is not cross-reactive with CD45.2 bearing cells.
Rahim T, Levinson MA, Carufe KEW, Burak M, Meas R, Maher S, Bothwell ALM, Gades N, Sweasy JB. The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation. PLoS One. 2022 Apr 29;17(4):e0267913. doi: 10.1371/journal.pone.0267913. PMID: 35486639; PMCID: PMC9053796.
Nishina T, Deguchi Y, Ohshima D, et a. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021 Apr 16;12(1):2281. doi: 10.1038/s41467-021-22450-3. PMID: 33863879.
|Name||FITC Anti-Mouse CD45.1 (A20)|
|Alternative Names||SJL, Ly5.1|
|Isotype||Mouse IgG2a, κ|