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Human peripheral blood lymphocytes were stained with 5 uL (1 ug) FITC Anti-Human CD45RO (35-0457) (solid line) or 1 ug FITC Mouse IgG2a isotype control (dashed line).

FITC Anti-Human CD45RO (UCHL1)

SKU 35-0457-T025
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The UCHL1 antibody reacts with the human CD45 isoform known as CD45RO, a protein tyrosine phosphatase of ≥ 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA and CD45RB.

The UCHL1 antibody is widely used as a marker for human CD45RO expression on thymocytes, activated memory T cells, monocytes, macrophages and granulocytes. The antibody is reported to be cross-reactive for Chimpanzee CD45RO.

Recent Publications:
Schumann K, Lin S, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Blueston JA, Doudna JA and Marson A. 2015. Proc Natl Acad Sci USA. DOI: 10.1073/pnas.1512503112. (Flow Cytometry)

Name FITC Anti-Human CD45RO (UCHL1)
Cat. No. 35-0457
Gene ID 5788
Clone UCHL1
Isotype Mouse IgG2a, κ
Reactivity Human
Cross Reactivity Chimpanzee
Format FITC
Application Flow Cytometry
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