The mouse monoclonal antibody PAC-1 recognizes an extracellular activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation.

PRODUCT DETAILS

Clone: PAC-1

Specificity: CD41/CD61

Reactivity: Human

Format: FITC

Isotype: Mouse IgM, k

Tested Dilution: 5 µL/Test

Application: FC

Storage: 2-8°C protected from light.Do not freeze

Formulation: Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: The suggested use of this reagent is 5 µL per 1 million cells in a staining volume of 100 µL. If whole blood is analyzed, then use 5 µL per 100 µL. It is recommended that users titrate the antibody to obtain the optimal result for their specific application. The content of a vial (0.5 mL) is sufficient for 100 tests.

REFERENCES

1. Shattil SJ, et al. 1985. J Biol Chem 260:11107-14.
2. Shattil SJ, et al. 1987. Blood 70:307-15.
3. Trikha M, et al. 1997. Cancer Res 57:2522-8.
4. Bourne JH, et al. 2021. Haematologica 106:626-629.

For research use only. Not intended for use in diagnostic procedures.