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Human peripheral blood lymphocytes were stained with 5 uL (0.5 ug) FITC Anti-Human CD3 (35-0039) (solid line) or 0.5 ug FITC Mouse IgG2a isotype control (dashed line).

FITC Anti-Human CD3 (Hit3a)

SKU 35-0039-T025
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The Hit3a antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.

The Hit3a antibody is a widely used phenotypic marker for human T cells. In addition, binding/cross-linking of Hit3a antibody to CD3e can induce cell activation. The antibody has also been demonstrated to be cross-reactive with Chimpanzee CD3. Please choose the appropriate format for each application.

Name FITC Anti-Human CD3 (Hit3a)
Cat. No. 35-0039
Alternative Names Leu-4, T3
Gene ID 916
Clone Hit3a
Isotype Mouse IgG2a, κ
Reactivity Human
Cross Reactivity Chimpanzee
Format FITC
Application Flow Cytometry
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