The mouse monoclonal antibody clone EBVCS-5 binds to human CD23, also known as the low-affinity IgE receptor (FceRII), a 45 kDa type II transmembrane protein and member of the immunoglobulin superfamily. It is expressed on most B cells and is upregulated upon activation. It is also present on mantle zone B cells, eosinophils, monocytes, and a subset of T cells and platelets. CD23 plays a role in B cell development and differentiation and also functions to regulate IgE production.

PRODUCT DETAILS

Clone: EBVCS-5

Specificity: CD23

Reactivity: Human

Format: FITC

Isotype: Mouse IgG1, k

Tested Dilution: 5 µL/Test

Application: FC

Storage: 2-8°C protected from light.Do not freeze

Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: The suggested use of this reagent is 5 µL per 1 million cells in a staining volume of 100 µL. If whole blood is analyzed, then use 5 µL per 100 µL. It is recommended that users titrate the antibody to obtain the optimal result for their specific application. The content of a vial (0.5 mL) is sufficient for 100 tests.

REFERENCES

1. Kintner, C., Sugden, B. 1981. Nature. 294: 458-60
2. Sugden B, Metzenberg S. 1983. J Virol. 46:800-7.

For research use only. Not intended for use in diagnostic procedures.