The mouse monoclonal antibody clone M80 binds to human CD141, a 75-kDa type I membrane glycoprotein. CD141, also known as thrombomodulin, BDCA-3, and fetomodulin. CD141 binds to its ligand, thrombin, to form a thrombin-thrombomodulin complex. This complex activates protein C and initiates the Protein C anticoagulant pathway. When bound to CD141, thrombin loses its ability to activate several pro-coagulant proteins. The molecule is expressed on macrophages, monocytes, dendritic cells, and vascular endothelial cells.

PRODUCT DETAILS

Clone: M80

Specificity: CD141

Reactivity: Human

Format: FITC

Isotype: Mouse IgG1, k

Tested Dilution: 5 µL/Test

Application: FC

Storage: 2-8°C protected from light.Do not freeze

Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: The suggested use of this reagent is 5 µL per 1 million cells in a staining volume of 100 µL. If whole blood is analyzed, then use 5 µL per 100 µL. It is recommended that users titrate the antibody to obtain the optimal result for their specific application. The content of a vial (0.5 mL) is sufficient for 100 tests.

For research use only. Not intended for use in diagnostic procedures.