cFluor® BYG750 Anti-Human CD56 (TULY56)
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The TULY56 monoclonal antibody binds to human CD56, a 120 to 180-kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. Depending on the cytoplasmic domain, CD56 exists in three main isoforms: NCAM-120, NCAM-140, and NCAM-1801. CD56, also known as NCAM (Neural Cell Adhesion Molecule), Leu-19 and NKH1, is present on NK and NKT cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Aberrant CD56 expression is observed in a range of hematological malignancies such as multiple myeloma and leukemia2 as well as in solid tumors such as lung cancer, ovarian cancer, and neuroblastoma3. The antibody was conjugated to a fluorophore and purified by chromatography.
Isotype: Mouse IgG1, κ
Tested Dilution: 5 μL / test
Application: Flow Cytometry
Storage: 2-8°C and protected from Light. Do not freeze
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% BSA (Origin USA)
Each lot of this antibody is quality control tested using flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per 1 million cells in a staining volume of 100 µL. If whole blood is analyzed, then use 5 µL per 100 µL. It is recommended that users titrate the antibody to obtain the optimal result for their specific application.
Please briefly centrifuge the reagent vial before use.
Use appropriate personal protective equipment per the product safety data sheet when using this product.
Van Acker HH, et al. 2017. Front Immunol. 8:892
Crossland DL, et al. 2018. Oncogene. 37(27):3686-3697
Seidenfaden R, et al. 2006. Neurochem Int. 49(1):1-11
These products are for research use only. Not intended for use in diagnostic procedures.
*cFluor® BYG750 is a tandem dye made with R-PE. Caution – Tandem dyes may show changes in their emission spectra with prolonged exposure to light or fixatives.