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Brilliant Violet 605™ anti-human CD158b/j (KIR2DL2/L3/S2)

Brilliant Violet 605™ anti-human CD158b/j (KIR2DL2/L3/S2)

SKU 312623
Regular price

$230.00

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Description

CD158b is expressed on natural killer cells and a subset of T cells. It is a member of the immunoglobulin superfamily containing two immunoglobulin C2-type domains. Both variants and alternative isoforms of CD158b have been reported. The interaction of CD158b with specific HLA-C antigens on a target cell (HLA-Cw1, HLA-Cw3, HLA-Cw7 alleles, for example) inhibits cytotoxicity and prevents target cell lysis and death. The interactions between KIR and MHC class I are thought to be important in NK cell and T cell regulation following antigen stimulation. The absence of ligands for KIRs may lower the threshold for activation through activating receptors and increase inflammation and susceptibility to autoimmune disease.


PRODUCT DETAILS

Clone: DX27

Antibody Type: Monoclonal

Reactivity: Human

Format: BV605

Host: Mouse

Isotype: IgG2a, κ

Applications: FC - Qulaity tested

Regulatory Status: RUO

Data Sheets: TDS | SDS



Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.

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