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C57Bl/6 splenocytes were stained with 0.125 ug Biotin Anti-Mouse CD3e (30-0031) (solid line) or 0.125 ug Biotin Armenian Hamster IgG isotype control (dashed line), followed by Streptavidin PE.

Biotin Anti-Mouse CD3e (145-2C11)

SKU 30-0031-U025
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The 145-2C11 antibody is specific for mouse CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.

The 145-2C11 antibody is a widely used phenotypic marker for mouse T cells. In addition, binding of 145-2C11 antibody to CD3e can induce cell activation. A recent publication of the crystal structure of a murine CD3e-mitogenic antibody complex provides further insight into the action of commonly used agonist antibodies (Fernandes, R.A. et al. 2012. J. Biol. Chem. 287: 13324-13335).


Recent Publications:

Aihara R, Kunimura K, Watanabe M, Uruno T, Yamane N, Sakurai T, Sakata D, Nishimura F, Fukui Y. DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation. Int Immunol. 2020 Sep 28:dxaa066. doi: 10.1093/intimm/dxaa066. PMID: 32986079.   

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Name Biotin Anti-Mouse CD3e (145-2C11)
Cat. No. 30-0031
Alternative Names CD3 epsilon
Gene ID 12501
Clone 145-2C11
Isotype Armenian Hamster IgG
Reactivity Mouse
Format Biotin
Application Flow Cytometry
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