TDS | SDS

The N418 antibody reacts with mouse CD11c, also known as integrin αalpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin αreceptors that mediate adhesion between ≥ ≥ ≥ cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin αs are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin αreceptors consist of distinct combinations of integrin αchains which are differentially expressed. integrin αalpha X (CD11c) assembles with integrin αbeta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

The N418 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on some types of activated T cells and intestinal intraepithelial lymphocytes (IEL).

Recent Publications:

Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. PMID: 35452291.

» View on PubMed

Racine JJ, Chapman HD, Doty R, Cairns BM, Hines TJ, Tadenev ALD, Anderson LC, Green T, Dyer ME, Wotton JM, Bichler Z, White JK, Ettinger R, Burgess RW, Serreze DV. T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue. J Immunol. 2020 Sep 16:ji2000114. doi: 10.4049/jimmunol.2000114. PMID: 32938729.

 » View on Journal of Immunology

Daisuke Morichika, Akihiko Taniguchi, Naohiro Oda et al. Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice. 04 August 2020. Research Square. https://doi.org/10.21203/rs.3.rs-52288/v1

Manz BN, Tan YX, Courtney A, Rutaganira F, Palmer E, Shokat KM and Weiss A. 2015. Elife. doi: 10.7554/eLife.08088. (Cell Separation)

Taniguchi A, Miyahara N, Waseda K, Kurimoto E, Fujii U, et al. 2015. Am J Physiol Lung Cell Mol Physiol. DOI: 10.1152/ajplung.00087.2015. (Flow Cytometry)