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The M1/70 antibody reacts with human and mouse CD11b, also known as integrin αalpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin αreceptors that mediate adhesion between ≥ ≥ ≥ cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin αs are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin αreceptors consist of distinct combinations of integrin αchains which are differentially expressed. integrin αalpha M (CD11b) assembles with integrin αbeta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells. The antibody is also reported to be cross-reactive for Rhesus macaque CD11b.

Recent Publications:

Racine JJ, Chapman HD, Doty R, Cairns BM, Hines TJ, Tadenev ALD, Anderson LC, Green T, Dyer ME, Wotton JM, Bichler Z, White JK, Ettinger R, Burgess RW, Serreze DV. T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue. J Immunol. 2020 Sep 16:ji2000114. doi: 10.4049/jimmunol.2000114. PMID: 32938729.

 » View on Journal of Immunology

Kamata T, So TY, Ahmed Q, et al. Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development. Cell Rep. 2020;31(12):107802. doi:10.1016/j.celrep.2020.107802.

Manz BN, Tan YX, Courtney A, Rutaganira F, Palmer E, Shokat KM and Weiss A. 2015. Elife. doi: 10.7554/eLife.08088. (Cell Separation)