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Human peripheral blood lymphocytes were stained with 0.125 ug Biotin Anti-Human CD45RO (30-0457) (solid line) or 0.125 ug Biotin Mouse IgG2a isotype control (dashed line), followed by Streptavidin PE.

Biotin Anti-Human CD45RO (UCHL1)

SKU 30-0457-U100
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The UCHL1 antibody reacts with the human CD45 isoform known as CD45RO, a protein tyrosine phosphatase of ≥ 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA and CD45RB.

The UCHL1 antibody is widely used as a marker for human CD45RO expression on thymocytes, activated memory T cells, monocytes, macrophages and granulocytes. The antibody is reported to be cross-reactive for Chimpanzee CD45RO.

Name Biotin Anti-Human CD45RO (UCHL1)
Cat. No. 30-0457
Clone UCHL1
Isotype Mouse IgG2a, κ
Reactivity Human
Cross Reactivity Chimpanzee
Format Biotin
Application Flow Cytometry
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