VISTA (V-domain Ig suppressor of T cell activation), also known as PD-1H, is a type I transmembrane protein with a single extracellular IgV domain. VISTA is expressed by a subset of T cells, macrophages, dendritic cells, neutrophils, and NK cells. It was reported that in certain tumor environment, there is low-pH dependent interaction between VISTA and PSGL1. However, the physiological binding partner for VISTA and the mechanism of its action are not clearly understood. VISTA is considered as a checkpoint regulator and a promising target for cancer immunotherapy.

PRODUCT DETAILS

Clone: A17002B

Antibody Type: Monoclonal

Reactivity: Human

Format: VISTA

Host: Mouse

Isotype: IgG2b, κ

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.