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SJL splenocytes were stained with 1 ug APC-Cy7 Anti-Mouse CD45.1 (25-0453) (solid line) or 1 ug APC-Cy7 Mouse IgG2a isotype control (dashed line).

APC-Cyanine7 Anti-Mouse CD45.1 (A20)

SKU 25-0453-U025
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$69.00

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Description

TDS | SDS

The A20 antibody reacts with mouse CD45.1, also known as Ly5.1, which is a strain-specific allelic form of the CD45 Leukocyte Common Antigen (LCA). Functionally, CD45 is a protein tyrosine phosphatase whose broad cell distribution supports a critical role in many leukocyte functions, including regulation of signal transduction and cell activation associated with the T cell and B cell receptors.

The A20 antibody is typically used as a leukocyte marker in Ly5.1 mouse strains: SJL/J, DA, STS/A and RIII. The antibody has been demonstrated to specific for CD45.1 and is not cross-reactive with CD45.2 bearing cells.

 

Recent Publications:

Fu Z, Dean JW, Xiong L, et al. Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Nat Commun. 2021 Jul 22;12(1):4462. doi: 10.1038/s41467-021-24755-9. PMID: 34294718.

» View on Nature Communications

Baba T, Yoshida T, Tanabe Y, et al. Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway. Cell Death Dis. 2021 Mar 26;12(4):322. doi: 10.1038/s41419-021-03587-x. PMID: 33771977.  

» View on Nature

Name APC-Cyanine7 Anti-Mouse CD45.1 (A20)
Cat. No. 25-0453
Alternative Names 25-0453, SJL, Ly5.1
Gene ID 19264
Clone A20
Isotype Mouse IgG2a, κ
Reactivity Mouse
Format APC-Cyanine7
Application Flow Cytometry
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