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C57Bl/6 splenocytes were stained with FITC Anti-Mouse NK1.1 (35-5941) and 0.06 ug APC Anti-Mouse KLRG1 (20-5893) (right panel) or 0.06 ug APC Golden Syrian Hamster IgG (left panel).

APC Anti-Mouse KLRG1 (2F1)

SKU 20-5893-U025
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The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).

The 2F1 antibody may be used as a phenotypic marker for KLRG1 in mouse, frequently in combination with Anti-Mouse CD127 antibody (clone A7R34), for identification of effector T cell populations.

Name APC Anti-Mouse KLRG1 (2F1)
Cat. No. 20-5893
Alternative Names  CLEC15A; MAFA; MAFA-2F1; MAFA-L; MAFA-LIKE
Gene ID 50928
Clone 2F1
Isotype Golden Syrian Hamster IgG
Reactivity Mouse
Format APC
Application Flow Cytometry
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