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Mouse macrophages were stimulated in the presence of a protein transport inhibitor. Cells were then fixed, permeabilized and stained intracellularly with 0.06 ug APC Anti-Mouse IL-12/IL-23 p40 (20-7123) (left panel) or 0.06 ug APC Rat IgG2a (left panel).

APC Anti-Mouse IL-12/IL-23 p40 (C17.8)

SKU 20-7123-U025
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The C17.8 antibody is specific for the 40 kDa (p40) protein subunit shared by the cytokines IL-12 and IL-23. To form IL-12, p40 assembles with a separate 35 kDa protein known as p35, resulting in a 70 kDa functional cytokine. IL-12 is secreted by activated monocytes, macrophages, and dendritic cells, and has been shown to target naive, resting CD4+ T cells to promote their proliferation and secretion of cytokines. IL-23 contains the p40 subunit in combination with a 19 kDa protein chain, p19; its primary source being activated dendritic cells and other antigen-presenting cells. IL-23 appears to target different cell types than IL-12, acting on memory CD4+ T cells to induce a strong proliferative response and contributing to the generation and expansion of Th17 cells. Like the cytokines themselves, the receptors for IL-12 and IL-23 share one subunit, as well as containing distinct cytokine-specific subunits.

As the C17.8 antibody binds to a shared subunit of both IL-12 and IL-23, it may be used as a marker for either IL-12 or IL-23 expression in dendritic cells, monocytes and macrophages, and is widely used for neutralization of activity associated with either cytokine. Please choose the appropriate format for each application.

Name APC Anti-Mouse IL-12/IL-23 p40 (C17.8)
Cat. No. 20-7123
Gene ID 16160
Clone C17.8
Isotype Rat IgG2a, κ
Reactivity Mouse
Format APC
Application Flow Cytometry
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