Helios is a member of the Ikaros family of zinc finger transcription factors. It contains a C-terminal region composed of 2 zinc-finger domains that mediate dimerization between the family members. Helios was originally cloned from a mouse thymoma line. It is mainly expressed in peripheral T cells and thymocytes. It is found at high levels in a subpopulation of regulatory T cells. Helios plays an important role in T cell development and homeostasis. Overexpression of Helios profoundly alters αβ T cell differentiation and activation. It has been determined that silencing of Helios in B cells is critical for maintaining normal B cell function. Helios is also involved in tumor immunity.

PRODUCT DETAILS

Clone: 22F6

Antibody Type: Monoclonal

Reactivity: Mouse, Human

Format: APC

Host: Armenian Hamster

Isotype: IgG

Applications: ICFC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

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