TDS | SDS

The GL-1 antibody reacts with mouse CD86, also known as B7-2, an 80 kDa cell surface protein which is a ligand for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 can also bind a second B7 ligand known as CD80 (B7-1). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between ≥ ≥ ≥ the B7 ligands and CD28 provides crucial communication between ≥ ≥ ≥ T cells and B cells or APCs to coordinate the adaptive immune response.

The GL-1 antibody may be used as a marker for CD86 expression on B cells, macrophages, and dendritic cells.

Recent Citations: 

Kotake K, Kumazawa T, Adachi T. Long-term administration of Tetragenococcus halophilus No. 1 over generations affects the immune system of mice. PLoS One. 2022 Apr 26;17(4):e0267473. doi: 10.1371/journal.pone.0267473. PMID: 35472068; PMCID: PMC9041805.

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