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C57Bl/6 splenocytes were stimulated with anti-IgM and anti-CD40 for 4 days. Cells were then stained with 0.06 ug APC Anti-Mouse CD80 (20-0801) (solid line) or 0.06 ug APC Armenian Hamster isotype control (dashed line).

APC Anti-Mouse CD80 (B7-1) (16-10A1)

SKU 20-0801-U025
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The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.

Recent Publications:
Chaganty BKR, Lu Y, Qiu S, Somanchi SS, Lee DA and Fan Z. 2015. OncoImmunology. DOI: 10.1080/2162402X.2015.1100790. (Flow Cytometry)

Name APC Anti-Mouse CD80 (B7-1) (16-10A1)
Cat. No. 20-0801
Alternative Names B7, Ly-53
Gene ID 12519
Clone 16-10A1
Isotype Armenian Hamster IgG
Reactivity Mouse
Format APC
Application Flow Cytometry
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