CD49b is a 150 kD glycoprotein, also known as α₂ integrin, VLA-2 α chain, Integrin α₂ chain, and HMα2. It is a member of the integrin family, expressed on NK cells, a subset of splenic CD4⁺ T cells, NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, epithelial cells, and platelets. By associating with CD29 (integrin β₁ subunit), CD49b forms the VLA-2 (integrin α₂β₁ ) complex. It plays a critical role in both adhesion and lymphocyte activation. The primary ligands for CD49b are collagen, laminin, and fibronectin. The HMα2 antibody has been shown to be useful for partially blocking CD49b mediated interactions with collagen. Additionally, this antibody blocks staining of splenic NK cells by the monoclonal antibody DX5.

PRODUCT DETAILS

Clone: HMα2

Antibody Type: Monoclonal

Reactivity: Mouse

Format: APC

Host: Armenian Hamster

Isotype: IgG

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

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