APC Anti-Mouse CD45.1 (A20)
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The A20 antibody reacts with mouse CD45.1, also known as Ly5.1, which is a strain-specific allelic form of the CD45 Leukocyte Common Antigen (LCA). Functionally, CD45 is a protein tyrosine phosphatase whose broad cell distribution supports a critical role in many leukocyte functions, including regulation of signal transduction and cell activation associated with the T cell and B cell receptors.
The A20 antibody is typically used as a leukocyte marker in Ly5.1 mouse strains: SJL/J, DA, STS/A and RIII. The antibody has been demonstrated to specific for CD45.1 and is not cross-reactive with CD45.2 bearing cells.
Miro-Mur F, Perez-de Puig I, Ferrer-Ferrer M, Urra X, Justicia C, Chamorro A and Planas AM. 2015. Brain Behav Immun. doi: 10.1016/j.bbi.2015.08.010. (Flow Cytometry)
|Name||APC Anti-Mouse CD45.1 (A20)|
|Alternative Names||SJL, Ly5.1|
|Isotype||Mouse IgG2a, κ|