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C57Bl/6 splenocytes were stained with FITC Anti-Mouse CD4 (35-0041), PE Anti-Mouse CD25 (50-0251) and 0.06 ug APC Anti-Mouse CD357 (GITR) (20-5874). Cells in the CD4+ lymphocyte gate are shown.

APC Anti-Mouse CD357 (AITR / GITR) (DTA-1)

SKU 20-5874-U025
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The DTA-1 antibody reacts with mouse CD357, also known as GITR or AITR (in humans), a 66-70 kDa member of the Tumor Necrosis Factor superfamily (TNFRSF18). GITR is primarily found on T cells, and its function may vary depending on the T cell type where it is expressed. GITR is upregulated on activated T cells where it provides co-stimulation, yet GITR may promote the inhibition of CD4+ CD25+ Treg cells, where it is expressed at high levels. GITR ligand (GITRL) is found on B cells, macrophages, dendritic and endothelial cells, and is implicated in regulating both innate and adaptive immune responses.

The DTA-1 antibody may be used for analysis of GITR expression on T cells, and is also commonly used in vitro as an agonistic antibody to induce GITR signaling in various assays (use format appropriate for functional assays).

Name APC Anti-Mouse CD357 (GITR) (DTA-1)
Cat. No. 20-5874
Alternative Names TNFRSF18
Gene ID 21936
Clone DTA-1
Isotype Rat IgG2b
Reactivity Mouse
Format APC
Application Flow Cytometry
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