Shopping Cart
APC anti-mouse CD283 (TLR3)

APC anti-mouse CD283 (TLR3)

SKU 141905
Regular price

$186.00

task_alt Added to cart.
View Cart or Continue shopping.
Description

Toll-like receptor 3 (TLR3), also known as CD283, is type I transmembrane protein that belongs to the TLR family. It forms a large horseshoe shape that contacts a neighboring horseshoe, forming a dimer of two horseshoes. It is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. TLR3 is expressed selectively on the cytoplasmic membrane and intracellularly in dendritic cells. It is also highly expressed in the placenta, pancreas, heart, liver, lung, and muscle. TLR3 is a pattern recognition receptor that participates in innate immune response to microbial pathogens by recognizing polyinosine-polycytidylic acid (Poly(I:C)) and dsRNA. Ligand binding by TLR3 induces receptor dimerization which results in inducing NF-κB activation (via TRIF-linked RIP1/TLR3 interactions) and cytokine production. TLR3 has been shown to interact with a number of proteins including MYD88, TRAF6, TRIAD3, MAP3K7, and TAB2.


PRODUCT DETAILS

Clone: 11F8

Antibody Type: Monoclonal

Reactivity: Mouse

Format: APC

Host: Rat

Isotype: IgG2a

Applications: ICFC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS



Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.

Shipping
Price calculated at checkout.