APC Anti-Mouse CD152 (CTLA-4) (UC10-4F10-11)
The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.
CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.
Kotake K, Kumazawa T, Adachi T. Long-term administration of Tetragenococcus halophilus No. 1 over generations affects the immune system of mice. PLoS One. 2022 Apr 26;17(4):e0267473. doi: 10.1371/journal.pone.0267473. PMID: 35472068; PMCID: PMC9041805.
Yoshida Y, Mikami N, Matsushima Y, Otani F, Miyawaki M, Takatsuji M, Banno R, Tsuji T, Fujita T, Tsujikawa K and Kohno T. 2015. Biol Pharm Bull. DOI:10.1248/bpb.b14-00873. (Flow Cytometry)
|Name||APC Anti-Mouse CD152 (CTLA-4) (UC10-4F10-11)|
|Alternative Names||Cytotoxic T Lymphocyte-Associated Antigen-4 (CTLA-4), Ly-56|
|Isotype||Armenian Hamster IgG|