APC Anti-Human CD49d (Integrin alpha 4) (9F10)
The 9F10 monoclonal antibody reacts with human CD49d, a 150kD integral membrane protein that is also known as integrin αalpha4 (ITGA4). Together with integrin αbeta1 (CD29), CD49d forms the VLA-4 heterodimer that serves as a receptor for fibronectin and VCAM-1. VLA-4 is widely expressed on lymphocytes, monocytes, thymocytes, and NK cells. CD49d can also dimerize with integrin αbeta7 to form a receptor that binds the mucosal vascular addressin molecule, MAdCAM-1. CD49d is involved in cellular adhesion to other cells as well as extracellular matrix.
|Name||APC Anti-Human CD49d (integrin αalpha 4) (9F10)|
|Alternative Names||VLA-4 ? chain, ?4 integrin α, integrin α?4 chain, ITGA4|
|Isotype||Mouse IgG1, kappa|