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APC Anti-Human CD49d (Integrin alpha 4) (9F10)
SKU 20-0499-T025
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Description
The 9F10 monoclonal antibody reacts with human CD49d, a 150kD integral membrane protein that is also known as integrin αalpha4 (ITGA4). Together with integrin αbeta1 (CD29), CD49d forms the VLA-4 heterodimer that serves as a receptor for fibronectin and VCAM-1. VLA-4 is widely expressed on lymphocytes, monocytes, thymocytes, and NK cells. CD49d can also dimerize with integrin αbeta7 to form a receptor that binds the mucosal vascular addressin molecule, MAdCAM-1. CD49d is involved in cellular adhesion to other cells as well as extracellular matrix.
| Name | APC Anti-Human CD49d (integrin αalpha 4) (9F10) |
|---|---|
| Cat. No. | 20-0499 |
| Alternative Names | VLA-4 ? chain, ?4 integrin α, integrin α?4 chain, ITGA4 |
| Clone | 9F10 |
| Isotype | Mouse IgG1, kappa |
| Reactivity | Human |
| Format | APC |
| Application | Flow Cytometry |