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Human peripheral blood lymphocytes were stained with 5 uL (0.125 ug) APC Anti-Human CD45 (20-0459) (solid line) or 0.125 ug APC Mouse IgG1 isotype control (dashed line).

APC Anti-Human CD45 (HI30)

SKU 20-0459-T025
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The HI30 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, CD45RO and others.

The HI30 antibody is widely used as a marker for human CD45 expression on T cells, B cells, monocytes, macrophages, and NK cells.

Recent Publications:

Pomicter AD, Clair PM, Yan D, Heaton WL, Eiring AM, Anderson MB, Richards SM, Gililland J, O'Hare T, Deininger MW. Femoral Heads from Total Hip Arthroplasty as a Source of Adult Hematopoietic Cells. Acta Haematol. 2021 Jan 7:1-7. doi: 10.1159/000511953. PMID: 33412552.

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Boyd DF, Allen EK, Randolph AG, Guo XJ, et al. Exuberant fibroblast activity compromises lung function via ADAMTS4. Nature. 2020 Oct 28. doi: 10.1038/s41586-020-2877-5. PMID: 33116313.

» View on Nature

Bachanova V, Frankel AE, Cao Q, Lewis D, Grzywacz B, Verneris MR, Ustun C, Lazaryan A, McClune B, Warlick ED, Kantarjian H, Weisdorf DJ, Miller JS, Vallera DA. 2015. Clin Cancer Res. 21(6): 1267-1272. (Flow Cytometry)

Name APC Anti-Human CD45 (HI30)
Cat. No. 20-0459
Alternative Names Leukocyte Common Antigen, LCA, Ly-5
Gene ID 5788
Clone HI30
Isotype Mouse IgG1, kappa
Reactivity Human
Cross Reactivity Chimpanzee
Format APC
Application Flow Cytometry
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