APC Anti-Human CD4 (OKT4)
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The OKT4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.
The OKT4 antibody is widely used as a phenotypic marker for CD4 expression. It is cross-reactive with CD4 in several non-human species, including Chimpanzee, Cynomolgus and Rhesus. This antibody recognizes a different epitope, and thus does not block binding of, the alternative Anti-Human CD4 antibody clone RPA-T4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065)
Diana R. Dou, Yang Zhao, Brian Abe, Rui Li, Lisa C. Zaba, Kathleen Aren, Mary Carns, Lorinda S. Chung, Monique Hinchcliff, Howard Y. Chang. Distinct T cell chromatin landscapes in scleroderma subtype. bioRxiv 2021.01.10.426131; doi: https://doi.org/10.1101/2021.01.10.426131.
|Name||APC Anti-Human CD4 (OKT4)|
|Alternative Names||Leu-3, T4|
|Isotype||Mouse IgG2b, kappa|
|Cross Reactivity||Chimpanzee, Cynomolgus, Rhesus|