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Human peripheral blood lymphocytes were stained with PE Anti-Human CD45 (50-0459) and 5 uL (0.125 ug) APC Anti-Human CD34 (20-0349) (right panel) or 0.125 ug APC Mouse IgG1 isotype control (left panel).

APC Anti-Human CD34 (4H11)

SKU 20-0349-T025
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The 4H11 monoclonal antibody reacts with human CD34, a single pass transmembrane protein with a molecular weight of 105-120 kDa. CD34 is heavily glycosylated with an N-terminal mucin domain. Although the function of CD34 is not defined, the intracellular domain of CD34 is a target for phosphorylation by activated protein kinase C, suggesting a possible role in signal transduction. CD34 is expressed on hematopoietic progenitor cells, some populations of mesenchymal stem cells, and vascular endothelium. The epitope of CD34 recognized by the 4H11 antibody is assigned to the class III epitopes. Additionally, CD34 may also function as an adhesion molecule with a role in mediating attachment of stem cells to bone marrow extracellular matrix, stromal cells, or other bone marrow components.

Name APC Anti-Human CD34 (4H11)
Cat. No. 20-0349
Clone 4H11
Isotype Mouse IgG1 k
Reactivity Human
Format APC
Application Flow Cytometry
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