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Human peripheral blood lymphocytes were stained with FITC Anti-Human CD4 (35-0048) and 5 uL (0.125 ug) APC Anti-Human CD25 (20-0259) (right panel) or 0.125 ug APC Mouse IgG1 isotype control (left panel).

APC Anti-Human CD25 (BC96)

SKU 20-0259-T025
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$44.00

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Description

TDS | SDS

The BC96 antibody is specific for human CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Signaling via CD25 may modulate Th17 and Treg cell differentiation, and has been shown to play a role in the function of dendritic cells.

The BC96 antibody may be used as a marker for expression of CD25 during T and B cell development, on activated mature T and B cells, and for its expression at high levels on natural T regulatory cells (nTreg cells) in the thymus or periphery, and on “induced” peripheral Tregs. This antibody is cross-reactive with CD25 in several non-human species, including Baboon, Chimpanzee, Cynomolgus and Rhesus.

Recent Publications:
Schumann K, Lin S, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Blueston JA, Doudna JA and Marson A. 2015. Proc Natl Acad Sci USA. DOI: 10.1073/pnas.1512503112. (Flow Cytometry)

Name APC Anti-Human CD25 (BC96)
Cat. No. 20-0259
Alternative Names Interleukin-2 Receptor alpha, IL-2Rα, IL2Ra, Tac
Gene ID 3559
Clone BC96
Isotype Mouse IgG1, kappa
Reactivity Human
Cross Reactivity Baboon, Chimpanzee, Cynomolgus, Rhesus
Format APC
Application Flow Cytometry
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