APC Anti-Human CD154 (CD40L) (5C8)
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The 5C8 antibody reacts with human CD154 which is also known as CD40L (CD40 ligand). CD154 is a 39kDa member of the TNF-α superfamily and is predominantly expressed on activated T cells but is also expressed on NK cells, mast cells, basophils, and eosinophils. CD154 binds to CD40, a molecule that is expressed on antigen presenting cells including B cells, monocytes/macrophages, and dendritic cells. The interaction of CD154 and CD40 regulates the activation of antigen presenting cells and is critical for B cell costimulation. The 5C8 antibody has been reported to block CD40L-CD40 interactions.
|Name||APC Anti-Human CD154 (CD40L) (5C8)|
|Alternative Names||CD40L, gp39, T-BAM, TRAP, Ly-62|
|Isotype||Mouse IgG2a, κ|
|Cross Reactivity||rhesus monkey, cynomolgus monkey|