APC Anti-Human CD11c (3.9)
The 3.9 antibody reacts with human CD11c, also known as integrin αalpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin αreceptors that mediate adhesion between ≥ ≥ ≥ cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin αs are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin αreceptors consist of distinct combinations of integrin αchains which are differentially expressed. integrin αalpha X (CD11c) assembles with integrin αbeta-2 (CD18) into a receptor known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.
The 3.9 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on activated neutrophils, granulocytes, some types of activated T cells and intestinal intraepithelial lymphocytes (IEL). The antibody is reported to be cross-reactive with Baboon, Chimpanzee, Cynomolgus and Rhesus CD11c.
He T, Yang D, Li XQ, Jiang M, Islam MS, Chen S, Chen Y, Yang Y, Chou CK, Trivett AL, Oppenheim JJ, Chen X. Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4+Foxp3+ regulatory T cells. Sci Adv. 2020 Sep 30;6(40):eaba6584. doi: 10.1126/sciadv.aba6584. PMID: 32998896.
|Name||APC Anti-Human CD11c (3.9)|
|Alternative Names||CR4, integrin αX, ITGAX|
|Isotype||Mouse IgG1, kappa|
|Cross Reactivity||Baboon, Chimpanzee, Cynomolgus, Rhesus|