Tau protein promotes microtubule assembly and stability. Tau is abundant in neurons of the central nervous system, and is expressed at low levels in astrocytes and oligodendrocytes. Abnormal hyper-phosphorylation, aggregation, and toxic gain of function of tau is associated with several neurological disorders, including Alzheimer’s disease (AD). The major building block of neurofibrillary lesions in AD brains consists of paired helical filaments (PHFs) of abnormally hyperphosphorylated tau. Six isoforms of tau are generated by alternative splicing of the MAPT gene. These isoforms are distinguished by the number of tubulin binding domains, 3 (3R) or 4 (4R), in the C-terminal of the protein and by one (1N), two (2N), or no (0N) inserts in the N-terminal domain. Tau isoforms are differentially expressed during development.

PRODUCT DETAILS

Clone: 43D

Antibody Type: Monoclonal

Reactivity: Human

Format: Alexa Fluor 647

Host: Mouse

Isotype: IgG1, κ

Applications: IHC-P -Quality tested IHC, WB - Reported in the literature, not verified in house

Regulatory Status: RUO

Data Sheets: TDS | SDS

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