ERG (ETS-related gene) is a member of the erythroblast transformation-specific (ETS) family of transcription factors. Expressed in the mesoderm and endothelium of embryos, ERG is vital to embryonic cell differentiation as well as regulation of endothelial homeostasis, a role it sustains beyond the embryonic stage. Through transcriptional regulation of VE-cadherin, ICAM-2, and Claudin-5, ERG maintains endothelial junctional integrity and stability and regulation of the endothelial cytoskeleton through its interactions with HDAC6 and RhoJ. ERG is vital to angiogenesis, bone development, platelet adhesion, urogenital tract development, vascular stability, and proper hematopoiesis regulation. It plays a large role in cellular response to vascular inflammation, endothelial cell barrier function, and inhibition of vascular inflammation. These functions are accomplished largely through ERG-mediation of the Wnt/β-catenin signaling pathway by means of transcriptional regulation of FZD4 and VE-cadherin by ERG and subsequent promotion of β-catenin stability. This in turn promotes endothelial cell proliferation. ERG fusion proteins resulting from chromosomal translocations cause ERG to behave as a proto-oncogene, contributing to prostate cancer, megakaryoblastic leukemia, and Ewing’s sarcoma.

PRODUCT DETAILS

Clone: W19256A

Antibody Type: Monoclonal

Reactivity: Human

Format: ERG

Host: Rat

Isotype: IgG2a, κ

Applications: ICC - Quality tested ICFC - Verified

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.