CD31, widely known as “platelet and endothelial cell adhesion molecule” (PECAM), is a crucial transmembrane glycoprotein primarily found on the surface of endothelial cells and platelets. The quintessential endothelial cell marker, CD31 is vital for the maintenance of vascular integrity. It plays a pivotal role in cell-cell adhesion, promoting interactions between neighboring endothelial cells, and facilitates leukocyte diapedesis during the inflammatory response. CD31 also mediates platelet-endothelial interactions, contributing to platelet aggregation and thrombus formation at sites of vascular injury. Additionally, this multifunctional molecule is involved in signal transduction pathways that govern cell migration, proliferation, and survival, making it a key player in immune response regulation and angiogenesis.

PRODUCT DETAILS

Clone: JC70

Antibody Type: Monoclonal

Reactivity: Human

Format: CD31

Host: Mouse

Isotype: IgG1, κ

Applications: IHC-P - Quality tested ICC, ICFC, FC - Verified

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.