Nuclear receptor subfamily 1, group D, member 2 (NR1D2), also known as Rev-ErbA β, is a member of the nuclear hormone receptor family. This protein can modulate gene expression by directly binding to DNA response elements within the promotor of its target genes as either monomers or homodimers. NR1D2 is well known to function as a transcriptional repressor. By complexing with heme, NR1D2 coordinates circadian rhythm and controls lipid metabolism. NR1D2 can directly repress the expression of core clock components ARNTL/BMAL1 and CLOCK, to coordinate circadian rhythm. In addition, NR1D2 can regulate lipid and energy homeostasis in skeletal muscles via repression of lipid metabolism and myogenesis-related genes such as CD36, FABP, SCD1 and MSTN. It is also involved in the regulation of hepatic lipid metabolism through the suppression of APOC3 expression. Not only as a repressor, NR1D2 also acts as a transcriptional activator; it can activate the transcription of the sterol regulatory element-binding protein 1 (STEBF1) and the inflammatory mediator IL-6 in skeletal muscle. Alternatively spliced transcript variants of NR1D2 gene have been described.

PRODUCT DETAILS

Clone: W15136A

Antibody Type: Monoclonal

Reactivity: Human, Mouse

Format: Alexa Fluor 594

Host: Rat

Isotype: IgG1, κ

Applications: ICC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.