Alexa Fluor® 594 anti-mouse CD172a (SIRPα)
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Description
CD172a, also known as SIRPα, is a type I transmembrane protein with one V-set Ig-like and two C-set Ig-like domains in the extracellular portion, and two ITIM motifs and a proline-rich region in the cytoplasmic tail. CD172a is expressed by monocytes, macrophages, myeloid cells, and neuronal tissue. The phosphorylation of SIRPα ITIMs induces the recruitment and activation of the tyrosine phosphatases PTPN6 and PTPN11, resulting in the negative regulation of several biological processes. The ligands of CD172a are CD47, SP-A, and SP-D.
PRODUCT DETAILS
Clone: P84
Antibody Type: Monoclonal
Reactivity: Mouse
Format: Alexa Fluor 594
Host: Rat
Isotype: IgG1, κ
Applications: IHC-F - Quality tested 3D IHC - Verified
Regulatory Status: RUO
Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.