Shopping Cart
Alexa Fluor® 488 anti-human CD357 (GITR)

Alexa Fluor® 488 anti-human CD357 (GITR)

SKU 371209
Regular price

$123.00

task_alt Added to cart.
View Cart or Continue shopping.
Description

GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18). GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR binds GITRL and is involved in the development of regulatory T cells and to regulate the activity of Th1 subsets.


PRODUCT DETAILS

Clone: 108-17

Antibody Type: Monoclonal

Reactivity: Human

Format: Alexa Fluor 488

Host: Mouse

Isotype: IgG2a, κ

Applications: FC - Quality tested

Regulatory Status: RUO

Data Sheets: TDS | SDS



Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.

Shipping
Price calculated at checkout.