CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells.

PRODUCT DETAILS

Clone: 104D2

Antibody Type: Monoclonal

Reactivity: Human

Format: Alexa Fluor 488

Host: Mouse

Isotype: IgG1, κ

Applications: FC - Quality tested SB - Reported in the literature, not verified in house

Regulatory Status: RUO

Data Sheets: TDS | SDS

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