The 37.51 antibody reacts with mouse CD28, a 45 kDa glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between ≥ ≥ ≥ the B7 ligands and CD28 provides crucial communication between ≥ ≥ ≥ T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of co-stimulatory receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA.

The 37.51 may be used as a phenotypic marker for CD28, which is expressed on all CD4+ T cells and CD8+ T cells, and on NK cells in mouse. In addition, the 37.51 antibody is widely used to activate the CD28 receptor in vitro and in vivo. Please choose the appropriate format for each application.

Name	In Vivo Ready™ Anti-Mouse CD28 (37.51)
Cat. No.	40-0281
Data Sheets	TDS \| SDS
Alternative Names	Tp44, T44
Gene ID	12487
Clone	37.51
Isotype	Golden Syrian Hamster IgG
Reactivity	Mouse
Format	In Vivo Ready™
Application	FC - Validated FA, IP - Reported in literature, not validated in house

For Research Use Only. Not intended for use in diagnostic procedures.

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