The antibody MEM-E/08 recognizes an extracellular epitope on native surface-expressed HLA-E, but not denaturated heavy chain of HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on many types of the human cells. The published results revealed that antibody is remarkably specific for HLA-E, only with weak cross-reactivity with following classical MHC Class I molecules (MHC Class Ia): HLA-A24, -B7, -B27, -B51, -B54, -C7.

PRODUCT DETAILS

Clone: MEM-E/08

Specificity: MHC Class I (HLA-E)

Reactivity: Human

Format: Purified

Isotype: Mouse IgG1

Application: FC, IP

Storage: 2-8°C protected from light.Do not freeze

Formulation: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: Recommended dilution: 4 μg/ml; positive control: human cell line LCL 721.221 (HLA-E transfected).

REFERENCES

1. Nachmani D, et al. 2014. PLoS Pathog 10:e1003963.
2. Gonen-Gross T, et al. 2005. J Immunol 175:4866-74.
3. Palmisano GL, et al. 2005. Hum Immunol 66:1-12.

For research use only. Not intended for use in diagnostic procedures.