The mouse monoclonal antibody clone 9F10 binds to human CD49d, a 150 kDa integral membrane protein known as integrin alpha4 (ITGA4). Together with integrin beta1 (CD29), CD49d forms the VLA-4 heterodimer that serves as a receptor for fibronectin and VCAM-1. VLA-4 is widely expressed on lymphocytes, monocytes, thymocytes, and NK cells. CD49d can also dimerize with integrin beta7 to form a receptor that binds the mucosal vascular addressin molecule, MAdCAM-1. CD49d is involved in cellular adhesion to other cells and the extracellular matrix. CD49d was also studied as a prognostic marker for disease progression and treatment options for chronic lymphocytic leukemia (CLL) and Duchenne muscular dystrophy (DMD).

PRODUCT DETAILS

Clone: 9F10

Specificity: CD49d

Reactivity: Human

Format: Purified

Isotype: Mouse IgG1, k

Application: FC

Storage: 2-8°C protected from light.Do not freeze

Formulation: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Data Sheets: TDS | SDS

RECOMMENDED USAGE

Flow cytometry: Recommended dilution: 0.5-4 μg/ml.
Immunohistochemistry: Recommended dilution: 5-10 μg/ml.

REFERENCES

1. Schlossman S, et al. 1995. Leucocyte Typing V. Oxford University Press. New York.

For research use only. Not intended for use in diagnostic procedures.