The p53 transcription factor is a tumor suppressor which regulates genome stability via the cell cycle, DNA repair, apoptosis, and senescence. It is activated in response to various cellular stresses including DNA damage. Mutations in TP53 gene are found in approximately half of all human cancers, making it one of the most mutated genes in cancer. These mutations often lead to loss of tumor-suppressing functions, contributing to uncontrolled cell proliferation and tumor development. Phosphorylation at Serine 15 is particularly important for p53 activation and function. This modification, often triggered by DNA damage, enhances p53 stability and its ability to activate target genes involved in cell cycle arrest and apoptosis. Without this phosphorylation, p53 ability to respond to stress signals and prevent tumorigenesis is significantly impaired.

PRODUCT DETAILS

Clone: P53S15-1C11.Rec

Antibody Type: Recombinant

Reactivity: Human

Format: p53 Phospho Ser15

Host: Rabbit

Isotype: IgG

Applications: ICFC - Quality tested ICC - Verified

Regulatory Status: RUO

Data Sheets: TDS | SDS

Note to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLegend, Inc. and Cytek Biosciences, Inc. Information related to this product is provided by BioLegend, Inc.